In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Glutathione, H2O2, & Red Blood Cells @ Metabolism Made Easy Hemolytic Anemias Part 4: G6PD Deficiency; Pathophysiology,Morphology, clinical features Glutathione redox cycle dysregulation in Huntington's disease knock in striatal cells ScienceDirect Glucose 6 phosphate Dehydrogenase (G6PD) Deficiency Concise Medical Knowledge The Redox Process in Red Blood Cells: Balancing Oxidants and Antioxidants